Página web del grupo: https://www.isciii.es/QuienesSomos/CentrosPropios/IIER/AreaGeneticaHumana/EpigeneticaRegulacionGenica/Paginas/Gruposinvestigacion.aspx
Investigador responsable: Pablo Gómez del Arco
. pgomez@isciii.es. IIER/ISCIII/CIBERCV
Entidad: Instituto de Salud Carlos III. IIER
Investigadores:
. IIER/ISCIIIRegulación Epigenética y Postranscripcional de la Función Cardiaca. IP: PABLO GÓMEZ DEL ARCO. Organismo financiador: Ministerio de Ciencia e Innovación Duración: 09/2021- 08/2024. Financiación: 121.000 €. Nº de Expediente: PID2020-114773GB-I00
1) El Abdellaoui-Soussi F, Yunes-Leites PS, López-Maderuelo D, García-Marqués F, Vázquez J, Redondo JM, Gómez-del Arco P. Interplay between the Chd4/NuRD Complex and the Transcription Factor Znf219 Controls Cardiac Cell Identity. International Journal of Molecular Sciences. 2022; 23(17):9565. doi:10.3390/ijms23179565
2) Sreenivasan K., Rodriguez de la Rosa A., Kim J., Mesquita D., Segalés, J., Gómez-del Arco P., Espejo I., Ianni A., Di Croce L., Relaix F., Redondo JM., Braun T., Serrano AL., Perdiguero E. and Muñoz-Canoves P. Chd4 ensures stem-cell lineage fidelity during skeletal muscle regeneration. Stem Cell Reports. 2021. doi: 10.1016/j.stemcr. 2021.07.022.
3) Novillo A., Fernández-Santander A., Gaibar M., Galán M., Romero-Lorca A., El Abdellaoui-Soussi F. and Gómez-del Arco P. Somatic mutations in the gene for chromodomain-helicase-DNA-binding protein 4 in breast cancer. Frontiers in Oncology. 2021. doi: 10.3389/fonc.2021.633233.
4) Sreenivasan K., Ianni A,, Künne C,, Strilic B,, Günther S,, Perdiguerro E., Krüger M., Spuler S., Offermanns S., Gómez-del Arco P., Redondo J.M, Munoz-Canoves P., Kim J. and Braun T. Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscles. Cell Reports. 2020. 19;31(7):107652.
5) Alvaro-Blanco J., Urso K., Chiodo Y., Martín-Cortázar C., Kourani O., Gómez-del Arco P., Rodríguez-Martínez M., Calonge E., Alcamí J., Redondo JM., Iglesias T., and MR. Campanero. MAZ induces MYB expression during the exit from quiescence via the E2F site in the MYB promoter. Nucleic Acids Research. 2017. 45(17): 9960-9975.
6) Kurusamy S., López-Maderuelo D., Little R., Cadagan D., Savage A.M., Ihugba J.C., Baggott RR, Rowther FB., Martínez-Martínez S, Gómez-del Arco P., Murcott C., Wang W., Nistal F.J., Oceandy D, Neyses L, Wilkinson R.N., Cartwright EJ, Redondo J.M. and A.L. Armesilla. Selective inhibition of plasma membrane calcium ATPase4 improves angiogénesis and vascular reperfusion. J. Mol. Cell. Cardiol. 2017. 109: 38-47.
7) Gómez-del Arco P*., Perdiguero E., Yunes-Leites P.S., Acín-Pérez R., Zeini M., García-Gómez A., Sreenivasan K., Jiménez-Alcázar M., Segalés J., López-Maderuelo D., Ornés B., Jiménez-Borreguero L.J., D´Amato G., Enshell-Seijffers D., Morgan B., Georgopoulos K., Islam AbuL B.M.M.K., Braun T., de la Pompa J.L., Kim J., Enriquez J.A., Ballestar E,, Muñoz-Cánoves P. and Redondo J.M*. *corresponding authors. The Chromatin Remodeling Complex Chd4/NuRD controls striated muscle identity and metabolic homeostasis. Cell Metabolism. 2016. 23: 881- 892.
8) MacGrogan D., D´Amato G., Travisano S., Martinez-Poveda B., Luxán G., del Monte-Nieto G., Papoutsi T., Sbroggio M., Bou V., Gómez-del Arco P., Gómez M.J., Zhou B., Redondo J.M., Jiménez-Borreguero L.J., de la Pompa J.L. Sequential ligand-dependent Notch signaling activation regulates valve primordium formation and morphogenesis. Circulation Research. 2016. 118 (10): 1480-1497.
